LOH12CR1 is a Novel Tumor Suppressor Inhibiting Tumor Growth Through Deregulation of Gl/S Checkpoint in Human Colorectal Carcinoma

摘要

Background: Loss of heterozygosity (LOH) of 12p12-13 has been frequently found in various types of cancer. LOH12CR1 is one of the seven critical genes located within the 12p12-13 region. The protein encoded by LOH12CR1 is involved in the function of lysosomes and its other functions are still unclear.