Cobalt(II)-Catalyzed Cross-Dehydrogenative Coupling Reaction of Benzamides with Alcohols to Build C-O Bond

摘要

abstract_textpA concise and efficient protocol for ortho-C-H alkoxylation of benzamides was developed via Co(II)-catalyzed cross-dehydrogenative coupling (CDC) reaction with alcohols. The reaction employs a Ag2O oxidant, a NaOAc base and alcohols solvent required as the alkoxylation source under N2 atmosphere. The method shows excellent functional group tolerance and highly regioselectivity, which provides a facile pathway for the ortho-alkoxylation of benzamides./p/abstract_text