Excretion of Hydroxy Derivatives of Polycyclic Aromatic Hydrocarbons of the Masses 178, 202, 228 and 252 in the Urine of Coke and Road Workers

摘要

Urinary PAH-metabolite excretion by non-exposed volunteers, temporarily living on a PAH-poor and PAH-rich diet, respectively, as well as by occupationally PAH-exposed coke plant workers and road workers has been studied. Significant differences in the amount of the metabolites excreted in the urine were detected; the ratio of various metabolites was also found to be different. The mass excretion per liter of the metabolites from phenanthrene was found to be for the unexposed volunteers about 3.5#x3BC;g/1, for coke plant workers about 70#x3BC;g/l and for road workers about 35 #x3BC;g/l. For the metabolites of chrysene the values were 0.03 #x3BC;g/1 2.5 #x3BC;g/l and 0.09#x3BC;g/l, respectively, and for the total metabolites of benzo(a)pyrene: 0.006#x3BC;g/l for unexposed persons, 0.37 #x3BC;g/l for coke plant workers and 0.019 #x3BC;g/l for road workers.