Effect of dietary fiber and butyric acid on lysosomal enzyme activities in streptozotocin-induced diabetic rats

摘要

The effect of dietary fiber and butyric acid on lysosomal enzyme activities in different tissues of streptozotocin-induced diabetic rats was studied by analyzing the specific activities of N-acetyl-beta-D-glucosaminidase, beta-D-glucuronidase, beta-D-galactosidase, and acid phos-phatase in various tissues. An alteration in the activities of these lysosomal enzymes in different tissues was observed in streptozotocin-induced diabetic rats. Dietary fiber and butyric acid supplementation at 500 mg/kg body weight/day was found effective in modulating the altered glycosidases activity in liver, spleen, heart, lungs, testis, and brain during diabetes. Our results also indicated that butyric acid along with dietary fiber is involved in minimizing the oxidative stress-induced tissue damage thereby regulating the altered enzyme activities in different tissues during diabetes.