Effects of Thromboxane Asub2/subReceptor Antagonist (Bay u 3405) on Nasal Symptoms after Antigen Challenge in Sensitized Guinea Pigs

摘要

To define the role of thromboxane A2 (TxA2) in allergic rhinitis, we examined the effects of the TxA2 receptor antagonist Bay u 3405 (1, 3 and 10 mg/kg, orally) on nasal symptoms, changes in total airway resistance (TAR), histamine hypersensitivity and eosinophil infiltration into the nasal mucosa induced by topical antigen challenge in actively sensitized guinea pigs. Nasal symptoms (number of sneezes and scratches) were significantly inhibited by pretreatment with Bay u 3405, in a dose-dependent manner. We noted a biphasic increase in TAR after antigen challenge. The first peak response of TAR (177.5 + 6.1, mean ± SE) was partially but significantly inhibited by Bay u 3405 at 10 mg/kg (142.8 ± 4.3, p2 may play an important role in allergic rhinitis in guinea pig mo