An individualised treatment algorithm for tumour stage 1 glottic squamous cell carcinoma

摘要

Objective: To report and discuss the outcome of a treatment algorithm for patients with tumour stage 1 glottic squamous cell carcinoma. Method: A retrospective outcome analysis study was performed using data from a tertiary referral centre. Results: Sixty-nine patients were treated with radiotherapy and 26 with surgery, in accordance with the treatment algorithm. Five-year overall survival rates were the same for both treatment groups (92 per cent). Five-year disease-specific survival rates were 100 per cent for surgery, 98 per cent for radiotherapy and 99 per cent overall. The overall 5-year laryngeal preservation rate was 89.1 per cent, being 95.7 per cent for surgery patients and 86.7 per cent for radiotherapy patients (p? =? 0.502). There was no significant association between laryngeal preservation rates and age (p? =? 0.779), anterior commissure involvement (p? =? 0.081), tumour stage (1a or 1b) (p? =? 0.266) or treatment modality (surgery or radiotherapy; p? =? 0.220). There was no significant difference in local recurrence rates between the two treatment groups (19.3 per cent for radiotherapy vs 10.0 per cent for surgery; p? =? 0.220). The overall 5-year regional recurrence rate was 1.2 per cent. Conclusion: Tumour stage 1 glottic carcinoma can be managed with different treatment modalities, following an individualised treatment algorithm, with results comparable to published outcomes.