A 9-year-old girl with Hutchinson-Gilford syndrome (progeria) was admitted with syncope. She had a cerebral infarction 8 months earlier. ECG showed ST segment depression in the lateral precordial leads. Because of the high prevalence of premature atherosclerosis in patients with progeria, she was referred for myocardial perfusion imaging using dipyridamole. The patient was given 0.56 mgsol;kg dipyridamole intravenously over 4 minutes followed 4 minutes later by 1 mCi TI-201 chloride. Subsequent to the dipyridamole infusion, the patient was free of symptoms. The ST segment depression in the lateral leads became more pronounced, but was nondiagnostic due to the baseline abnormalities
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