Heat shock and UV-B-induced DNA damage and mutagenesis in skin

摘要

There is evidence that heat pre-treatment protects cultured human keratinocytes and normal murine and human skin from ultraviolet(UV)radiation-induced cell death.It has been suggested that heat-shock proteins(hsps),particularly hsp72,are involved in this effect.Hsps are expressed in response to various types of stress,such as UV radiation.Whether heat shock interferes with the repair of UV-induced DNA damage and whether this can be regarded as a protective mechanism is poorly understood and needs further experimental investigation.This review gives an overview of the current state of research in the area.