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Gender-related differences in atherosclerosis

机译:动脉粥样硬化的性别相关差异

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摘要

Atherosclerotic cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. Considerable research has been done over the last several decades to understand the pathophysiology of atherosclerosis. It is widely believed that estrogen is responsible for the protection of women from CVD in the premenopausal age group. However, hormone replacement therapy has failed to decrease CVD events in clinical studies which points to the complexity of the relationship between vascular biology and estrogen hormones. Interestingly, preponderance of vascular and connective tissue disorders in women also points to an inherent role of hormones and tissue factors in maintenance of vascular endothelial function. The differential effect of GPER, lipoprotein A, TLRs, leucocyte-platelet aggregate markers in men and women also suggests inherent gender-related differences in the pathophysiology of atherosclerosis. A better understanding of the pathophysiology is likely to open ways to improve evidence-based treatment of CVD in women.
机译:动脉粥样硬化性心血管疾病(CVD)是全球发病和死亡的主要原因。在过去的几十年里,已经进行了大量研究来了解动脉粥样硬化的病理生理学。人们普遍认为,雌激素负责保护绝经前年龄组的妇女免受心血管疾病的侵害。然而,激素替代疗法在临床研究中未能减少心血管疾病事件,这表明血管生物学与雌激素之间关系的复杂性。有趣的是,女性血管和结缔组织疾病的普遍性也表明激素和组织因子在维持血管内皮功能方面的固有作用。GPER、脂蛋白 A、TLR、白细胞-血小板聚集标志物在男性和女性中的差异效应也表明动脉粥样硬化的病理生理学存在固有的性别相关差异。更好地了解病理生理学可能会为改善女性心血管疾病的循证治疗开辟道路。

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