The antiischemic effects of tedisamil were investigated in chronically instrumented conscious dogs. Heart rate, arterial blood pressure, left ventricular dP/dtmax, left ventricular end-diastolic pressure, and regional myocardial shortening in the ischemic and normal myocardium, assessed by sonomicrometry, were measured. Reversible regional myocardial dysfunction was achieved by graded treadmill exercise in the presence of a critical coronary stenosis, which was produced by partial inflation of a hydraulic occluder. Regional myocardial dysfunction, which was observed befere the intravenous drug administration, was almost completely abolished by tedisamil (180 μg/kg/5min). The antiischemic effect of tedisamil is due to a reduction in heart rate, which leads to a decrease in left ventricular dP/dtmaxand myocardial oxygen demand in the presence of a prolongation of diastole and thus coronary perfusion time. Clinical evaluation will test the value of this drug for the treatment of stress-induced symptomatic and asymptomatic angina pectoris in humans
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