Dose response and induction of tolerance to the synthetic antigen (T,G)‐A–L in adult rabbits

摘要

AbstractThe immunogenicity of the synthetic multichain polypeptide (T,G)‐A–L in rabbits was investigated under a variety of conditions. The polymer led to antibody production with as little as four micrograms in complete Freund's adjuvant per immunization. The pattern of antibody formation as a function of time varied from dose to dose, the highest initial response corresponding to the lowest dose administered. The synthetic polypeptide was immunogenic also when incorporated in an alum precipitate, but not when injected intravenously in buffered saline. Tolerance to (T,G)‐A–L was produced in adult rabbits upon intravenous in