Growth Hormonesol;Insulinhyphen;Like Growth Factor Axis in Human Immunodeficiency Virushyphen;Associated Disease

摘要

NA;The growth hormone lpar;GHrpar;sol;insulinhyphen;like growth factor lpar;IGFrpar; axis is an essential component of the endocrine system for stimulating postnatal growth in children and maintaining lean body mass in adults. It may be more than coincidental, therefore, that impaired growth and muscle wasting are common symptoms of human immunodeficiency virus lpar;HIVrpar; infection in children and adults. Wasting and growth failure contribute significantly to the morbidity and mortality associated with AIDS. Multiple defects in the GHsol;IGF axis have been reported in patiients with AIDS. These include abnormal GH secretion and tissue responsiveness, diminished serum concentrations of IGFhyphen;I and hyphen;II, and abnormall posthyphen;translational modifications of IGF binding proteins. In this review we examine the hypothesis that the failure to thrive lpar;in childrenrpar; and the loss of lean body mass lpar;in adultsrpar; may be agehyphen;related manifestations of AIDS that, in part, result from defects in the GHsol;IGF axis.