AbstractDay‐time sleep and residual effects of quazepam 15 mg, triazolam 0·25 mg, flunitrazepam 1 mg, and placebo, alone and in combination with ethanol, were studied using a randomized, double‐blind, crossover, single‐dose design. Eight healthy volunteers, four male and four female, aged 19–24 years, received each medication in the morning after a ‘normal’ sleep at home the preceding night.Quazepam and triazolam decreased the sleep onset when compared to placebo. The combination with ethanol did not change these findings. Quazepam and placebo showed less residual effects than triazolam and flunitrazepam at 4 hours after drug intake: in combination with ethanol at 4 and 6 hours. No significant differences in mood were found between the different ‘treatments’, except with regard to alertness for quazepam and placebo compared to flunitrazepam, alone and in combination with ethanol, all at 4 hours.The combination drug/ethanol showed an increase inCmaxof the former and a delay inTmaxwhen compared to drug alone. The study indicated few clinically useful correlations between clinical effect and plas
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