Efficacy of an Immunoglobulin Preparation from HIV Carriers in Preventing HIV Replication in vitro

摘要

Abstract.Immunoglobulin samples (HIV‐Ig) were prepared by cold ethanol fractionation of human plasma containing antibody against human immunodeficiency virus (HIV). The ability to prevent viral spreading was studied using either human T‐cell leukemia virus type I (HTLV‐I)‐carrying MT‐4 cells or in a coculture system using MOLT‐4 cells and virus‐producing MOLT‐4/HIVHTLV‐IIIBcells. Treatment of HIV‐infected MT‐4 cells with HIV‐Ig effectively blocked the appearance of antigens of HIV and the virus‐induced cytopathic effect. HIV‐Ig blocked multinucleated giant cell formation in the MOLT‐4 and MOLT