MYELIN DEFICIENCY IN HEREDITARY PITUITARY DWARFISHA BIOCHEMICAL AND MORPHOLOGICAL STUDY

摘要

Myelin in the central nervous system of 19-day-old Snell's dwarf mice was studied morphologically and biochemically. The number of myelinated axons per unit area in the corticospinal tract and anterior commissure of dwarf mice was significantly decreased. The distribution of myelinated fibers based upon sheath thickness was normal. The yield of isolated myelin was decreased by 56percnt; in the dwarf but its composition of lipids, proteins, glycoproteins and 2',3,-cyclic nucleotide 3'-phosphohydrolase activity was nearly equivalent to that of control myelin.