NA;Recent evidence suggests that longhyphen;chain saturated fatty acids lpar;i.e. stearic acidrpar;, produced on lipolysis of triglyceridehyphen;rich lipoproteins in the interface of circulating remnant particles provide a contact surface that activates the contact system of coagulation and subsequently activates factor VII. Increased level of circulating activated factor VII is probably of little consequence to a healthy individual with minimal expression of tissue factor in the vasculature. However, at a site of an atheromatous plaque or at a vascular injury site where there is tissue factor activity, increased circulating activated factor VII is expected to generate thrombin at a higher rate. Propagation of the prothrombotic environment will be facilitated on expression of additional tissue factor that is induced by the local increased concentration of thrombin. Thrombin with its receptorhyphen;mediated interactions with blood and vessel wall cells can signal inflammatory and proliferative responses such as those that occur in atheroma.
展开▼
