Quantitative Histology of Bone in Hyperparathyroidism

摘要

Bone biopsies have been examined quantitatively in 24 patients with, hyperparathyroidism (21 primary, 2‘tertiary’, and 1 hypohyperparathyroidism) and the results compared with those of X-ray, plasma calcium and alkaline phosphatase, and urinary total hydroxyproline (THP) excretion. The clinical usefulness of bone biopsy has been assessed. Bone resorption and formation (measured as osteoid) are increased in nearly all cases and X-rays often fail to detect this. In individual cases THP excretion may be a more useful indicator of bone disease than is plasma alkaline phosphatase. It is postulated that all patients with hyperparathyroidism have abnormal bones, irrespective of clinical presentat