Recent experimental studies have indicated a 'vomiting pattern generator' (formerly called the 'vomiting center') situated in the dorsal portion of the lateral reticular formation of the medulla, which mostly corresponds to the dorsal vagal complex (DVC) 1. There is also a chemosensitive trigger zone in the floor of the fourth ventricle in the area postrema, which lies just adjacent to the DVC 2,3. When accompanied by vertigo or raised intracranial pressure, brain diseases often cause nausea and vomiting. However, isolated central vomiting is rare.
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