We report on the rare combination of multiple sclerosis (MS) and cerebral glioblastoma in a 50-year-old deceased male. MS was not diagnosed clinically. The particularities of the case in comparison with the known data from the literature are the partly more active MS plaques and extensive necroses of the glioblastoma, especially on the tumourous margins, immediately in the neighbourhood of MS plaques. The possible causes for the unusual coincidence are discussed.
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