Excretion studies on sodium tyropanoate (Bilopaque sodium) were perfomed on dogs having a modified Thomas cannula in the duodenum opposite the ampulla of Vater. The data from these studies were compared with those from earlier studies previously performed in the same dogs with sodium iopanoate (sodium salt of Telepaque). Although we found the gross kinetics of the two drugs quite similar, sodium tyropanoate caused a choleresis that led to the excretion of a more dilute solution of contrast material in hepatic bile. Crossover studies on two of these same dogs indicate that the choleresis is not related to any temporal changes in the animal preparation.
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