First Molecular Cytogenetic Characterization of Murine Malignant Mesothelioma Cell Line AEl7 and silico Translation to the Human Genome

摘要

Background: Mesothelial cells can be malignantly transformed e.g. due to previous asbestos exposure and form a clinically aggressive tumor called malignant mesothelioma (MM). Presently, there is extensive ongoing research in MM with the goal to identify prognostic factors and new therapeutic targets. Accordingly, well studied model systems, like cell lines, are urgently needed. Interestingly, murine MM cell lines models were established in the 1990s; however, they were not characterized genetically in any detail, yet.