Peripheral T‐cell Lymphoma of AILD (Angioimmunoblastic Lymphadenopathy with Dysproteinemia) Type Involving Gastrointestinal Tract

摘要

A case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) which showed widespread involvement of the gastrointestinal tract is reported. A lymph node biopsy specimen showed the characteristic histological features of AILD. During the progression of the illness, lymphomatous lesions developed in the gastrointestinal tract, complicated by cytomegalovirus infection. A double immunoenzymatic study using a combination of Ki 67 antibody and antibodies against surface antigens demonstrated that CD3+, CD4., and/or T cell receptor (TCR) beta+cells were predominant (67–68) among the population of proliferating Ki 67+cells, rather than CD8+or CD22+cells. Clonal rearrangement of the TCR beta chain gene was also detected. These findings provide further evidence for the neoplastic nature of lesions of this type, and the diagnosis of peripheral T cell lymphom