Intra-abdominal sepsis

摘要

Intra-abdominal sepsis is usually a complication of intra abdominal infection, secondary to gastrointestinal tract perforation or loss of intestinal barrier integrity. Consecutive spread of enteric bacteria and (endo)toxins is followed by the release of inflammatory mediators (cytokines) causing a systemic inflammatory response, and eventually immunoparalysis and (septic) multi-organ dysfunction. Eradication of the infection focus, together with appropriate antibiotic therapy and supportive intensive care, are the cornerstones of treating abdominal sepsis. Therapeutic strategies aimed at influencing the immune response have been attempted but have not yet proved to be effective in controlled clinical trials