NA;Sodium diatrizoate (Hypaque) was administered intravenously to rats 45 to 60 minutes after unilateral or bilateral ureteral ligation. Ninety minutes later, the kidneys were removed from the living animals and quick‐frozen. Contact microradiographs (CMR) of freeze‐dried frozen sections of the tissue demonstrated that the relative distributions of the radiopaque material were the same in the obstructed and non‐obstructed kidneys, although the obstructed kidneys had greater total amounts. No significant amounts of Hypaque were collected in the interstitial tissues of either the normal or obstructed kidneys. This study indicates that the mechanism of excretion of Hypaque is the same in the obstructed kidney as in the non‐obstructed kidney. A novel CMR apparatus was built for this study. Special techniques of microradiography and section freezedrying were developed to preserve the water‐soluble contrast material.
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