Fresh frozen plasma therapy in acute pancreatitis: an experimental study

摘要

Fresh frozen plasma therapy was assessed in a rat model of acute haemorrhagic pancreatitis incorporating the facility for continuous intravenous infusion in the unrestrained animal. Infusions including fresh frozen plasma were shown to significantly improve 72 h survival in the model compared to crystalloid (P<0.001) and colloid (P<0.05) control groups. The mechanism of this improved survival has yet to be elucidated, but this work supports the establishment of a controlled clinical trial of fresh frozen plasma therapy in this disease.