Morphological details of metaphase chromosomes were compared among 12 inbred strains of rats (Rattus norvegicus) by means of conventional Giemsa staining and by a sequential Q- and C-banding method. Interstrain variations were found in seven pairs, as identified on the basis of size differences in the short arms and/or satellites of chromosomes 3 and 12 and the X chromosome and in the centromeric C-bands of chromosomes 4, 5, 7, and 9. All pairs were homomorphic in the inbred strains, while F1 hybrids between two inbred strains showed certain heteromorphic pairs expected from the parents. These chromosome markers appear to be useful for characterization of inbred strains as well as for various genetic studies, including linkage analyses.
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机译：通过常规 Giemsa 染色和顺序 Q 和 C 条带方法比较了 12 个近交系大鼠 （Rattus norvegicus） 中期染色体的形态学细节。在七对中发现了菌株间变异，这是根据 3 号和 12 号染色体以及 X 染色体的短臂和/或卫星以及 4、5、7 和 9 号染色体的着丝粒 C 带的大小差异确定的。所有对在自交系中都是同态的，而两个自交系之间的F1杂交种显示出某些来自亲本的异态对。这些染色体标记似乎可用于表征近交系以及各种遗传研究，包括连锁分析。
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