Access to 3-Aroylchromanones from Dibenzoylmethanes via an Iron-Catalyzed alpha-Methylenation Reaction

摘要

A simple and straightforward synthesis of 3-aroylchromanones based on a tandem iron catalyzed alpha-methylenation - intramolecular oxy-Michael addition reaction of dibenzoylmethanes with N,N-dimethylacetamide is described. The reaction employs FeCl3 as catalyst under aerobic conditions to afford the corresponding 3-aroylchromanones and tolerates a variety of substituents on both aromatic rings.