Urographic Excretion Studies with Metrizamide and ldquo;Dimerrdquo;colon; A High Dose Comparison in Dogs

摘要

Metrizamide, a new non-ionic, triodinated contrast agent has been considered for intravenous urography. Theory predicts that lower osmotic diuresis with this agent should lead to higher urinary iodine concentrations than with ionic agents, at equivalent iodine doses. However, a distinct advantage with metrizamide has not been observed with doses of 175 mglsol;kg or less. In this study metrizamide and sodium iocarmate were given intravenously to dehydrated dogs at a dose level of 600 mglsol;kg. During the studies the concentrations and outputs of major urinary solutes were compared. Comparisons of urinary iodine concentrations and outputs showed that at this dose the predicted advantage with metrizamide can be observed.