The effects of alpha- and beta-adrenergic stimulation on guinea pig eosinophil functions were studied. Both enhanced glucose uptake of eosinophils at a concentration of 5 × 10––5M after a 24-hour incubation. Decreased eosinophil chemotaxis and dose-dependent inhibition of arylsulfatase release from eosinophils induced by opsonized Candida albicans were observed when eosinophils were incubated with beta-adrenergic agents, but not with alpha-adrenergic agents. On the other hand, alpha stimulation inhibited phagocytosis of opsonized C. albicans by eosinophils and NBT reduction at concentrations of 8 × 10––5 and 5 × 10––5M, respectively, but beta stimulation at the same concentrations did not. This suggests that the regulatory effect of adrenergic agents on phagocytosis in eosinophils is different from that in macrophages and polymorphonucl
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