Cytolytic T cell hybridomas II. Interleukin 2‐independent cytolytic variants

摘要

AbstractInterleukin 2 (IL 2)‐dependent cytolytic hybrids usually loose IL 2 dependence and cytolytic activity concomittantly. Here we describe an exceptional IL 2‐independent variant which lost IL2 receptor but retained cytolytic activity. When the IL 2‐independent cytolytic hybrid cells were fused with IL 2‐dependent cytolytic clones which express IL2 receptors constitutively, IL 2‐dependent hybrids were obtained. This suggests that the expression of IL 2 receptors can interfere with IL 2‐independent growth