Serial hepatic arteriographic portal venographic, and hepatic venograpbic studies were carried out in cholecystectomized dogs subjected to extrahepatic total or lobar choleslasis. Injection preparations of the biliary and arterial trees were made on livers removed post mortem. The angiographic patterns were described and measurements of the vascular diameters were carried out. The diameters of the arteries supplying cholestatic liver lobes increased significantly during the first week of biliary obstruction. After 2 weeks a decrease in arterial diameter was observed in cases not complicated with portal vein thrombosis. Tortuosity and cork-screw appearance of arterial branches were noted, increasing with time of cholestasis and extending to even the most peripheral arteries, visible after 3 weeks. The portal venograms displayed irregularity in contour, changing of caliber and increase in the angle of ramification, as well as a high incidence of portal vein thrombosis. Hepatic venograms displayed alterations comparable to those in the portal vein.
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