Comparative chromosomal mapping of the owl monkey serum albumin gene

摘要

We have mapped the albumin locus (ALB) in the owl monkey, Aotus trivirgatus, using a cloned human albumin gene probe, pcHSA 33-1. Rodent-owl monkey somatic cell hybrids were used to map the owl monkey albumin locus in three subgroups of Aotus, karyotypes II, V, and VI. Segregation analysis of the molecular hybridization pattern of pcHSA 33-1 in the somatic cell hybrids indicated that the albumin locus maps to chromosome 9 of owl monkey karyotype II, chromosome 12 of karyotype V, and chromosome 1 of karyotype VI. This assignment provides evidence for the homology of these three chromosomes and supports the hypothesis of Ma on the formation of chromosome 1 in karyotype VI.