The Relationship between pKaand Skin Irritation for a Series of Basic Penetrants in Man

摘要

The Relationship between pKaand Skin Irritation for a Series of Basic Penetrants in Man. BERNER, B., WILSON, D. R., STEFFENS, R. J., MAZZENGA, G. C., HINZ, R., GUY, R. H., AND MAIBACH, H. I. (1990).Fundam. Appl. Toxicol15, 760–766. For a series of bases, which penetrate through human skinin vitroat similar rates (0.056–0.49μM/cm²/hr), penetrant pKais shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a pKa>8. The irritation potential of acids with pKa≤4 has been previously reported; pKaappears highly predictive of acute skin irritation for acids and bases