Association between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis

摘要

Abstract Pro-inflammatory cytokines such as leptin and IL-6 play an important role in the development of cardiovascular risk. Determine the relationship between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis. We determined IL-6 and leptin levels in 77 patients with the diagnosis of rheumatoid arthritis. The cardiovascular risk was calculated using the modified Framingham scale. Statistical analysis was performed using SPSS 22 considering a significant p ? p 0.047), obesity ( p 0.038), positive rheumatoid factor ( p 0.009), tobacco ( p 0.009), and metabolic syndrome ( p 0.001). Likewise, a significant relationship was found between lower leptin concentrations and hydroxychloroquine consumption ( p ?=?0.023). We found significant difference between IL-6 concentrations and disease activity ( p 0.028), hypertriglyceridemia ( p 0.023), LDL-C ( p 0.029), and smoking (0.005). Similarly, an association between hydroxychloroquine consumption and low concentrations of IL-6 was found ( p 0.005). Framingham CVR was calculated and the result obtained was multiplied by 1.5. The 35.2 of the population studied had a low Framingham CVR, 38.9 moderate, and 25.9 presented a high risk. We compared the level of CVR and serum leptin and IL-6 concentrations, finding that the highest CVR was the leptin and IL-6 values. There is a positive association between CVR and serum leptin concentrations. It is also significantly associated with traditional and non-traditional risk factors.