Over a 15-year period six patients (five female) of Afro-Caribbean origin presented with ulcerative colitis from a community of this ethnic extraction numbering 47 000 persons. The disease was characterised by an acute severe presentation, extensively affected bowel, an active course of disease and a propensity for severe hypersensitive reactions to oral suphasalazine. These findings are of particular implication in the management of ulcerative colitis in West Indians.
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