Seventeen consecutively treated patients with advanced gastric cancer were prescribed every 3 weeks intravenous cisplatin (20 mg/m2/day) and a continuous infusion of 5-fluorouracil (5-FU) (750 mg/m2/day) for 5 days. Twelve (71percnt;) patients had been treated previously with other anticancer drugs. Seven (42percnt;) patients showed a partial response and these responses persisted for over 4.4 months. Stabilization of the disease occurred in eight (47percnt;) patients, and in two (12percnt;) the disease progressed. At the time of analysis, mean survival of the responders was 8.2 months, while that of non-responders was 5.0 months. The toxicities were within acceptable limits and only a few had a grade III toxicity. This combined administration of cisplatin and 5-FU for 5 days is safe and effective for patients with advanced gastric cancer.
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