Zur Synthese von 9,9-Dimethyl-2-oxa-bicyclo3.3.1nonan

摘要

The diketone1undergoes base induced ring opening to the δ-ketoacid2 a. Subsequent stereoselective reduction of the carbonyl-group affords the corresponding hydroxyacid4 aand condensation leads to the bicyclic lactone5which can be reduced to the title compound6. Similar O-cage-compounds are known for antiviral activity. The olfactory properties of the compounds5and6are described