Effects of Manganese Dipyridoxyl Diphosphate, Dipyridoxyl Diphosphatendash; ndash;, and Manganese Chloride on Cardiac FunctionAn Experimental Study in the Langendorff Perfused Rat Heart

摘要

RATIONALE AND OBJECTIVES.Manganese dipyridoxyl diphosphate (MnDPDP) is a promising contrast agent for magnetic resonance imaging of the liver. The authors explored the possibility that high concentrations of MnDPDP may cause manganese ion (Mnplus;plus;)-induced side effects on cardiac function.METHODS.Potential cardiodepression by MnDPDP, DPDPndash; ndash;, and manganese chloride (MnCl2) (100-3,0000 micro;mol/ L) was investigated in the isolated rat heart, with left ventricular developed (systolicmdash;end-diastolic) pressure and heart rate as the primary indices of cardiac function.RESULTS.During 5-minute exposures, 10percnt; and 50percnt; decreases in left ventricular developed pressure were observed for MnDPDP, 250 micro;molsol;L and 1580 sol;micro;moIsol;L; DPDPndash; ndash;, less than 100 micro;molsol;L and 1000 sol;micro;moIsol;L; MnCl2, 30 sol;micro;molsol;L and 250 sol;micro;molsol;L. Heart rate changes were not observed with MnDPDP. Cardiodepression was reversed within 2 minutes during a 14- minute recovery period for all investigated concentrations of MnDPDP and was less rapid for the highest concentrations of MnCl2.CONCLUSIONS.Manganese dipyridoxyl diphosphate is well tolerated in the rat heart at concentrations as high as 200 to 250 limolsol;L and is approximately 10 times less cardiotoxic than MnCl2. Cardiodepressive effects of MnDPDP in the present rat heart model, perfused in the absence of blood and proteins, are related primarily to the release of free Mnplus;plus;ions and in part to the simultaneous release of DPDPmacr; macr;.