PurposeTo evaluate the incidence and origin of abnormal focal pulmonary uptake during myocardial perfusion SPECT imaging (MSPECT).MethodsFor evaluation of chest pain, 790 men and 581 women (mean age, 56 plusmn; 13 years) underwent MSPECT. All of them received adenosine for pharmacologic stress and Tc-99m tetrofosmin (TF, n equals; 817) or Tc-99m sestamibi (MIBI, n equals; 554) for myocardial perfusion imaging.ResultsReview of chest radiography with or without computed tomography revealed 111 (8.1percnt;) focal pulmonary diseases. Among them, 38 (34.2percnt;) showed focal pulmonary uptake (TF, 22; MIBI, 16); 27 (30.7percnt;) of 88 showed previous pulmonary tuberculosis; 2 of 10 (20percnt;) benign pulmonary nodules; 4 of 5 (80percnt;) metastatic lung cancers; 2 of 4 (50percnt;) primary lung cancers; and 3 of 4 (75percnt;) pneumonias. No difference in uptake was noted for the two imaging agents. Intensity of uptake did not vary with origin of the uptake. Focal abnormal pulmonary uptake was found in 2.8percnt; of patients undergoing MSPECT and in 34.2percnt; of patients in whom radiological examinations showed regional pulmonary disease. In patients with abnormal pulmonary uptake on MSPECT, 16percnt; had a malignant lesion, whereas 75percnt; of patients with a pulmonary nodule shown on radiography and focal pulmonary uptake on MSPECT had a malignant lesion.ConclusionsAlthough the incidence of abnormal pulmonary uptake during MSPECT was very low, the incidence of malignant lesions in the patients with nodular pulmonary uptake was relatively high.
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