Evidence for a role of CD28RE as a response element for distinct mitogenic T cell activation signals

摘要

AbstractT lymphocytes can be induced to produce interleukin (IL)‐2 and proliferate upon T cell receptor (TcR) occupancy together with a CD28‐induced co‐stimulatory signal. The T cell surface molecule CD28 is believed to function as a regulator in T cell activation at both the level of lymphokine mRNA stabilization and gene transcription. Activation of IL‐2 gene transcription via CD28 has been shown to be mediated through a xB‐like sequence, called CD28RE. DNA binding analysis revealed that the CD28‐induced signal is involved in the induction of CD28RE binding activity. Here, we demonstrate that the induction of CD28RE binding activity is not specific for the CD28‐induced signal. Our data indicate that distinct mitogenic T cell activation signals converge on the induction of CD28RE binding activity, and suggest a crucial role for this activity in the IL‐2 enhancer responsiveness to different modes of T