Much research has shown that iron store parameters are increased in women with polycystic ovary syndrome (PCOS), but an exact explanation for this phenomenon remains unavailable. The objective of this study was to investigate the correlation between iron status parameters and hormonal disturbances in women with PCOS that accounts for their increased iron store levels. Iron status parameters and hormones were measured using colorimetric and enzyme-linked immunosorbent assays, respectively. The results demonstrated a mild iron overload in the patients with PCOS. Good positive correlations between iron status parameters and serum testosterone, prolactin, and insulin were detected in the patient group, whereas iron status parameters and BMI were not significantly correlated. The data also suggest that the increase in serum ferritin and body iron store levels in patients with PCOS are associated with hyperandrogenemia, hyperprolactinemia, and hyperinsulinemia. The findings of this study expand current knowledge on the factors affecting iron stores and suggest a different mechanism of interaction between iron stores and the endocrine system through the harmful deposition of iron in endocrine glands and through hormonal effects on iron absorption and metabolism.
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