Fasting glucagon-like peptide 1 concentration is associated with lower carbohydrate intake and increases with overeating

摘要

PurposeGlucagon-like peptide 1 (GLP-1) is an incretin hormone that appears to play a major role in the control of food intake. The aim of this investigation was to evaluate and quantify the association of circulating GLP-1 concentration with ad libitum total calorie and macronutrient intake.MethodsOne-hundred and fifteen individuals (72 men) aged 3510years were admitted for an inpatient study investigating the determinants of energy intake. Ad libitum food intake was assessed during 3days using a reproducible vending machine paradigm. Fasting plasma GLP-1 concentrations were measured on the morning of the first day and on the morning of the fourth day after ad libitum feeding.ResultsPlasma GLP-1 concentrations increased by 14 after 3days of ad libitum food intake. Individuals overate on average 13945 of weight-maintaining energy needs. Fasting plasma GLP-1 on day 1 was negatively associated with carbohydrate intake (r=-0.2, p=0.03) and with daily energy intake from low fat-high simple sugar (r=-0.22, p=0.016).Conclusion Higher plasma GLP-1 concentrations prior to ad libitum food intake were associated with lower carbohydrate intake and lower simple sugar ingestion, indicating a possible role of the GLP-1 in the reward pathway regulating simple sugar intake.Trial registration ClinicalTrials.gov identifier: NCT00342732.