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Experimental models of urinary bladder outlet obstruction

机译:膀胱出口梗阻的实验模型

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AbstractUrinary bladder obstruction has been the subject of numerous clinical and experimental studies. The most common experimental model for outlet obstruction requires the surgical creation of a bladder outlet obstruction and then determining the effects after specific periods of time. These studies have demonstrated that the bladder responds to obstruction with rapid and significant changes in bladder structure and function. Although much important information comes from experimental surgical obstruction, this model is not appropriate for the study of the initial effects of outlet obstruction. The in‐vitro whole bladder model (rabbit) can be utilized to study the initial effects of outlet obstruction on the physical characteristics of bladder emptying. This model has the advantage of one being able to have complete control of the type and magnitude of obstructio
机译:摘要膀胱梗阻是众多临床和实验研究的主题。最常见的出口梗阻实验模型需要通过手术创建膀胱出口梗阻,然后在特定时间段后确定效果。这些研究表明,膀胱对梗阻的反应是膀胱结构和功能发生快速而显着的变化。尽管许多重要信息来自实验性手术梗阻,但该模型不适合研究出口梗阻的初始影响。体外全膀胱模型(兔子)可用于研究出口梗阻对膀胱排空物理特性的初步影响。该模型的优点是能够完全控制障碍物的类型和大小。

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