Testes of 6 rats were processed routinely for electron microscopy and, as an incidental finding, interstitial (Leydig) cells were found to contain bundles of unusual cylindrical bodies or macrotubules. These cytoplasmic structures were found in testes of only 2 of the 6 rats and varied in number from 2 to 346 per cell profile, usually in parallel array but with an irregular orientation in approximately 5 of the cells. The macrotubules were up to 11 μm long, showed a diameter of 130 nm with a wall of 18–20 nm and an inside diameter of about 94 nm. The wall appeared to be formed by two membranes 6–7 nm thick showing a unit membrane structure with a central electron-lucent space of 6 nm. In several instances, the wall membranes appeared corrugated, which may account for the apparent formation of the wall by a spiralling small tubule or tubules of 18 nm diameter. Several macrotubules showed continuity between their wall membranes and elements of endoplasmic reticulum and occasionally two adjacent macrotubules showed continuity at their ends in a U-form. Similar if not identical structures have been described previously in four studies of interstitial cells of the rat renal medulla, in one instance correlated with water-deprivation. They have been considered an alteration in the endoplasmic reticulum. Also, they have been reported in pig uterine glands in pregnancy. They may represent a cellular response to an unrecognized physiopathological s
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