Considerable substernal activity was revealed during thyroid imaging (I-123 sodium iodide and Tc-99m pertechnetate) of two women. This activity did not clear completely on swallowing water, and achalasia was suggested. This was confirmed in both cases by radiographs after ingestion of contrast material. The differential diagnosis of substernal activity on these scans includes ectopic thyroid, vascular masses, and achalasia.
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