AbstractWound healing substance (WHS) from culturedClostridium perfringenshas been reported to be effective in the treatment of wounds. The effects of WHS, now named SNK‐863, on proliferation and differentiation of human keratinocytes were examined.The characteristics of WHS are as follows: 1) WHS stimulates human keratinocyte growth and DNA synthesis; 2) WHS and EGF show some additive effects on human keratinocyte growth; 3) WHS does not interfere with the binding of EGF to its receptor; 4) WHS does not counteract the growth inhibitory effects of TGF‐β or vitamin D3on human keratinocytes; 5) WHS has no significant effect on human keratinocyte differentiation. These results indicate that the growth‐promoting effect of WHS on keratinocytes may contribute to the treatment of wound h
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