In vitro susceptibility ofClostridium perfringensisolated from farm animals to growth‐enhancing antibiotics

摘要

Minimal inhibitory concentration (MIC) determinations were carried out with seven growth‐enhancing antibiotics against 95Clostridium perfringensfield isolates obtained during 1991 and 1992 from poultry, pigs and calves. All were resistant to 64 μg ml−1of the bambermycin antibiotic, flavomycin (flavophospholipol) and susceptible to avoparcin (MIC900.25 μg ml−1), avilamycin (MIC900.5 μg ml−1) and salinomycin (MIC90≤ 0.12 μg ml−1). Acquired resistance against bacitracin was detected in some isolates from poultry and bovines and resistance to tylosin and virginiamycin in some strains from all species investigated. Overall, the prevalence of resistance was comparable to the low levels recorded in 1979 inCl. perfringensisolates from the same anim