MR signal abnormalities were assessed in 87 symptom-free volunteers (31–83 years of age) and correlated with cerebrovascular risk factors, cerebral blood flow and glucose metabolism. Lesions in the subcortical and deep white matter increased from 11 in the 4th decade to 83 in subjects over 70 years of age, and were detected significantly more often in individuals with cerebrovascular risk factors (p < 0.01). They were associated with lower slow-compartmental flow (p < 0.05) but did not affect adjacent cortical glucose metabolism. Periventricular signal changes also increased with age but were unrelated to risk factors or functional dat
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