Observations on induction, duration and recovery after thiopentone, as modified by glucose, physostigmine and bemegride, were made on twelve dogs, every dog acting as his own control. Glucose, together with thiopentone, caused no significant change in induction time, while the duration of anaesthesia and recovery period was prolonged. Physostigmine and bemegride delayed the onset of anaesthesia after thiopentone and shortened the duration and recovery timings, and they antagonized the glucose potentiation of thiopentone anaesthesia. The action of these antagonisms has been discussed as a non-specific one. It is concluded that the duration of surgical anaesthesia with thiopentone can be prolonged by simultaneous intravenous administration of glucose, and this prolongation can be cut short at will by administration of drugs like physostigmine and bemegride.
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