Anti‐IgG Autoantibodies in HIV‐infected Hemophilia Patients

摘要

AbstractSera of 76 HIV‐negative hemophilia patients, 103 HIV‐positive (HIV+) hemophilia patients free of AIDS or AIDS related complex (ARC), and 32 HIV+ hemophilia patients with AIDS/ARC were tested for four different anti‐IgG activities. IgG‐anti‐F(ab')2γ, IgM‐anti‐F(ab')2γ, and IgG‐anti‐Fcγserum activities were significantly associated with the clinical stage of HIV infection, whereas IgM‐anti‐Fcγwas not. IgG‐anti‐F(ab')2γactivity was found to be caused by cross‐reaction of anti‐HIV antibody with an epitope within the constant CHI domain of human IgG. HIV+ hemophilia patients with severe thrombocytopenia (50,000/μl platelets. Because anti‐IgG antibodies possess immunoregulatory properties, our results may serve as a possible explanation for the frequent B cell diso